Cardiac and neuroprotection regulated by α1-adrenergic receptor subtypes
نویسندگان
چکیده
منابع مشابه
Cardiac pressure overload hypertrophy is differentially regulated by β-adrenergic receptor subtypes.
In isolated myocytes, hypertrophy induced by norepinephrine is mediated via α(1)-adrenergic receptors (ARs) and not β-ARs. However, mice with deletions of both major cardiac α(1)-ARs still develop hypertrophy in response to pressure overload. Our purpose was to better define the role of β-AR subtypes in regulating cardiac hypertrophy in vivo, important given the widespread clinical use of β-AR ...
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α1-Adrenergic receptors (α1-ARs) are important players in peripheral and central nervous system (CNS) regulation and function and in mediating various behavioral responses. The α1-AR family consists of three subtypes, α1A, α1B and α1D, which differ in their subcellular distribution, efficacy in evoking intracellular signals and transcriptional profiles. All three α1-AR subtypes are present at r...
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Intermolecular interactions between members of both similar and divergent G protein–coupled receptor subfamilies have been shown in various experimental systems. Here, we demonstrate heterodimerization of predominant -adrenergic receptor ( AR) subtypes expressed in the heart, 1AR, and 2AR, and its physiological relevance. In intact adult-mouse cardiac myocytes lacking native 1AR and 2AR, coexpr...
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ژورنال
عنوان ژورنال: Journal of Receptors and Signal Transduction
سال: 2011
ISSN: 1079-9893,1532-4281
DOI: 10.3109/10799893.2010.550008